Hemorrhagic encephalitis as a primary manifestation of lymphomatoid granulomatosis: case report
Encefalitis hemorrágica como manifestación primaria de granulomatosis linfomatoide: reporte de un caso
How to Cite
Download Citation
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Show authors biography
Most read articles by the same author(s)
- Maria Isabella Bonilla Arbelaéz, D’angelo Clavijo Salazar, Juan Felipe Cruz López, Daniela Duque Montoya, Concurrent Guillain-Barré syndrome and longitudinally extensive myelopathy secondary to SARS-CoV-2 infection. Case report , Archivos de Medicina : Vol. 24 No. 2 (2024): Archivos de Medicina (Manizales)
Lymphomatoid granulomatosis is an angiocentric, angiodestructive lymphoproliferative disorder that affects multiple organs, but is most common in the lungs. It is pathologically characterised as being associated with a proliferation of B lymphocytes, related to the Epstein-Barr virus. Lymphomatoid granulomatosis affects the central nervous system secondarily in 25-30% of cases, but lymphomatoid granulomatosis involving primarily and only the CNS is extremely rare, with only 49 cases reported in the literature. We report the case of a 21-year-old boy with isolated primary lymphomatoid granulomatosis of the central nervous system, who presented with a clinical manifestation of his patho-logy; his diagnostic approach was made by diagnostic imaging and confirmed by biopsy.
Article visits 131 | PDF visits 94
Downloads
- Colby TV. Current histological diagnosis of lymphomatoid granulomatosis. Mod Pathol [Internet]. 2012;25 Suppl 1(S1):S39-42. Disponible en: http://dx.doi.org/10.1038/modpathol.2011.149
- Swerdlow SH, Campo E, Pileri SA, Lee Harris N, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016 May 19;127(20):2375–90
- Roschewski M, Wilson WH. Lymphomatoid granulomatosis. Cancer J [Internet]. 2012;18(5):469–74. Disponible en: http://dx.doi.org/10.1097/PPO.0b013e31826c5e19
- Katzenstein A-LA, Doxtader E, Narendra S. Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surg Pathol [Internet]. 2010;34(12):e35-48. Disponible en: http://dx.doi.org/10.1097/PAS.0b013e3181fd8781
- He C, Wang Y, Zhang L, Lu C, Ge W, Zhang Q, et al. Isolated lymphomatoid granulomatosis of the central nervous system: A case report and literature review. Neuropathology [Internet]. 2019;39(6):479–88. Disponible en: http://dx.doi.org/10.1111/neup.12605
- Xiang Y, Liu C, Xue Y, Li S, Sui Y, Li J, et al. Primary central nervous system lymphomatoid granulomatosis: Systemic review. Front Neurol [Internet]. 2020;11:901. Disponible en: http://dx.doi.org/10.3389/fneur.2020.00901
- Gupta T, Wadasadawala T, Shet T, Jalali R, Menon H. Isolated central nervous system involvement by lymphomatoid granulomatosis in an adolescent: a case report and review of literature. Pediatr Hematol Oncol [Internet]. 2010;27(2):150–9. Disponible en: http://dx.doi.org/10.3109/08880010903536185
- Gaha M, Souillard-Scemama R, Miquel C, Godon-Hardy S, Naggara O, Meder J-F. MR imaging of the brain and spinal cord in lymphomatoid granulomatosis: a case report and review of the literature. J Neuroradiol [Internet]. 2013;40(5):364–7. Disponible en: http://dx.doi.org/10.1016/j.neurad.2012.12.001
