Tamizaje virtual de compuestos inhibidores de la SAP-2 de Candida albicans.

Juan Rebollo; Niradiz Reyes; Paola Suárez

doi:10.30554/archmed.15.2.675.2015

Virtual screening of inhibitory compounds SEP-2 Candida albicans

Tamizaje virtual de compuestos inhibidores de la SAP-2 de Candida albicans.

Published 2015-12-31

https://doi.org/10.30554/archmed.15.2.675.2015

Open | Download

PDF (Spanish) FLIP HTML (Spanish)

Issue

Vol. 15 No. 2

Section

Artículos de Investigación

How to Cite

Rebollo, J., Reyes, N., & Suárez, P. (2015). Virtual screening of inhibitory compounds SEP-2 Candida albicans. Archivos De Medicina , 15(2), 260-265. https://doi.org/10.30554/archmed.15.2.675.2015

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

DOI

https://doi.org/10.30554/archmed.15.2.675.2015

Dimensions

PlumX

How to Cite

Rebollo, J., Reyes, N., & Suárez, P. (2015). Virtual screening of inhibitory compounds SEP-2 Candida albicans. Archivos De Medicina , 15(2), 260-265. https://doi.org/10.30554/archmed.15.2.675.2015

Download Citation

license

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Juan Rebollo

Doctorando, Grupo de genética y biología molecular. Sección de Microbiología, Facultad de Medicina, Universidad de Cartagena. Jeanrebollo@gmail.com

Niradiz Reyes

Docente, Grupo de genética y biología molecular. Sección de Microbiología, Facultad de Medicina, Universidad de Cartagena. nreyesr@unicartagena.edu.co

Paola Suárez

Docente, Grupo de Micología. Sección de Microbiología, Facultad de Medicina, Universidad de Cartagena. psuareza@unicartagena.edu.co

Show authors biography

Juan Rebollo,

Grupo de Micología. Docente Sección de Microbiología. Facultad de Medicina. Universidad de Cartagea

Most read articles by the same author(s)

Oscar Montes, Rosa Milanés, Alvaro Alvarez, Sandra Coronado, Niradiz Reyes, molecular characteristics and antibiotic susceptibility of Staphylococcus aureus strains colonizing patients with nasal pathologies , Archivos de Medicina : Vol. 15 No. 2

candida albicans

antifiungal

protease inhibitors

indinavir.

Objetive: reports of Antifungal resistance to Candida spp. are increasing nowadays. Candida spp. is an opportunistic yeast associated to many different mucocutaneous and systemic diseases. Because of this problematic is necessary to search others new selective and specific compounds against this fungi. Virtual docking is a good alternative to study new molecules. Materials and Methods: here we analyse 13418 compounds
similar to recognized inhibitors of SAP-2, the enzyme selected as antifungal target. SYBYL 8 was the program used to do the docking virtual besides Autodock Vina to finally select the compounds with best scores. Results: similar compounds to protease inhibitors, amprenavir, indinavir, ritonavir shows best scores in virtual docking. Conclusion: the results suggest that similar compounds to protease inhibitors, amprenavir, indinavir and ritonavir could be proposed as model to research new molecules with antifungal activity against Candida spp.

Article visits 422 | PDF visits 306