Chronic use of non-steroidal anti-inflammatory drugs and its association with the development of hypertensive crisis: a narrative review

Consumo crónico de antiinflamatorios no esteroideos y su relación con el desarrollo de crisis hipertensiva: una revisión narrativa

Introduction: Arterial hypertension is defined as high blood pressure, generally speaking of a systolic that reaches at least 140 mmHg and/or an elevation of diastolic blood pressure of at least 90 mmHg. For its part, hypertensive crisis does not have a standardized definition, but it is known as a sudden or acute increase in blood pressure with compromise of the target organ.

Objectives: The main objective of this study was to describe the chronic consumption of non-steroidal anti-inflammatory drugs and its relationship with the development of hypertensive crises.

Discussion: Around 10 studies were found that report increased systolic and diastolic pressure after the consumption of certain NSAIDs such as naproxen, ibuprofen and indomethacin. The increase in pressure for this group of drugs ranges from 14 to 20%.

Conclusion: NSAIDs do not reach the necessary levels for the induction of a hypertensive crisis, however, there is limited literature that reports possible cases of hypertensive crisis secondary to the use of these, for this reason, it is relevant to expand the study of the possibility of crises. hypertensive. for this pharmacological group.