Plasmatic levels of Interleukin-1β (IL-1β) in Patients Diagnosed with Sepsis and Septic Shock in the Intensive Care Unit of a Clinic in the City of Cali

Niveles Plasmáticos de la Interlucina-1 β (IL-1β) en pacientes colombianos con sepsis y choque séptico

Introduction. Sepsis represents a high risk of mortality. In this study, plasma levels of IL-1β were evaluated as a biomarker of bacterial sepsis in patients from a clinic in the city of Cali.
Materials and methods. We conducted a prospective study in 62 patients with sepsis and 20 healthy adults as control, using the ELISA test to measure plasma levels of cytokines. The analysis of the odds ratio (OR), expressed with its 95% confidence intervals (95% CI) for the outcome of sepsis in relation to the levels of IL-1β. The Chi-square test and the Mann-Whitney U test will be applied when appropriate, the p values <0.05, and the statistical data of the SPSS statistical package. Vs 23.00
Results. The average age of the patients were 53 years and they were in the ICU of 7.00 days, 59.7% of them were men. The pulmonary focus (43.5%), arterial hypertension (41.9%) and gram negative bacteria (59.7%) were the most prevalent with a mortality of 16.1%. The high levels of IL-1β were associated with the development of septic shock (OR = 28,050, 95% CI 5,512-142,740, P = 0,000) and with respiratory failure (OR = 9,009, 95% CI: 0.013-0.941, P = 0.019). .
Conclusion. We found significant differences in IL-1β levels during the first 48 hours in patients with septic shock. However, the plasma level of the cytokine is not related to mortality.