Beta-Thalassemia: A world of complications with new alternatives of treatment

Beta-Talasemia: Un mundo de complicaciones con nuevas alternativas de tratamiento.

β-thalassemia is caused by mutations in the HBB globin gene, which encodes the β subunit of HbA. The disease is known to be highly prevalent in the area that stretches from sub-Saharan Africa, through the Mediterranean region and the Middle East. In Colombia, several independent studies of hemoglobinopathies have been reported in cities such as Cartagena, Buenaventura, Cali, San Andrés and Providencia due to their large Afro-descendant population on wich the thalassemias and other hemoglobinopathies.have direct incidence. Objective: to collect data about the clinical characteristics, complications and classifications of β-thalassemia in order to provide a source of information that allows an effective diagnosis and a treatment that seeks to reach the complete cure of patients that have this condition. , with the minimum of complications for them. Conclusion: β-thalassemia is a structural hemoglobinopathy that has a percentage of prevalence and incidence important in the world. In Colombia it is not clear what is the real epidemiology for this condition that has not been conducted studies that include an adequate and significant sample.This disease generates multiple complications in different organs, but not only in long-term transfusion therapy. For this reason, the new treatments are aimed at achieving complete healing in the future, minimizing complications at maximum