Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical

Publicado 2019-07-24


https://doi.org/10.30554/archmed.19.2.3298.2019
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v. 19 n. 2 (2019)
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González Andrade, F., Castillo Rojas, A. ., & Aguinaga Romero, G. (2019). Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood: Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical. Archivos De Medicina , 19(2). https://doi.org/10.30554/archmed.19.2.3298.2019
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https://doi.org/10.30554/archmed.19.2.3298.2019
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González Andrade, F., Castillo Rojas, A. ., & Aguinaga Romero, G. (2019). Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood: Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical. Archivos De Medicina , 19(2). https://doi.org/10.30554/archmed.19.2.3298.2019

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Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fabricio González Andrade
Central University of Ecuador, Faculty of Medical Sciences, Traslational Medicine Unit. Address: Iquique N14-121 and Sodiro-Itchimbía, Sector El Dorado, 170403, Quito, Ecuador. Phone: +593 9984536414
Andrea Castillo Rojas
Central University of Ecuador
Perfil Google Scholar
https://orcid.org/0000-0002-4878-4700 ORCID
Gabriela Aguinaga Romero
Central University of Ecuador
https://orcid.org/0000-0002-6274-2195 ORCID
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Andrea Castillo Rojas,

Translational Medicine Unit, Faculty of Medical Sciences at Central University of
Ecuador. Quito, Ecuador

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Background: to determine the relationship and association of early sepsis with interleukin-6 measured in umbilical blood, as well as gestational age and birth weight, prenatal history of the mother pathologies during pregnancy, in full-term newborns at the Neonatology Service of Carlos Andrade Marín Hospital (Quito). Subjects and methods: epidemiological, observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams,  cutoff point interleukin 6 ≤14pg/uL; mean of IL6. 58±99,1 pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, prenatal infection of the urinary tract 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship of prenatal pre-maternity of the mother and neonatal sepsis. p<0.05; relationship between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia, prenatal urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: It is concluded that there is a relationship of risk factors, such as, gestational age in weeks, weight, prenatal preeclampsia, prenatal UTI, vaginitis/vaginosis and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.

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