Cáncer colorrectal: una mirada clínica, genética y molecular./Colorectal cancer: clinical, molecular and genetics view

Brenda Lucia Arturo Arias; Natalia García Restrepo; Paula Tatiana Uribe Echeverry; Jhon Fredy Betancur Pérez

doi:10.30554/archmed.13.2.14.2013

Colorectal cancer: clinical; molecular and genetics view

Cáncer colorrectal: una mirada clínica, genética y molecular./Colorectal cancer: clinical, molecular and genetics view

Published 2013-12-15

https://doi.org/10.30554/archmed.13.2.14.2013

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Vol. 13 No. 2

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Artículos de Revisión

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Arturo Arias, B. L., García Restrepo, N., Uribe Echeverry, P. T., & Betancur Pérez, J. F. (2013). Colorectal cancer: clinical; molecular and genetics view. Archivos De Medicina , 13(2), 208-219. https://doi.org/10.30554/archmed.13.2.14.2013

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https://doi.org/10.30554/archmed.13.2.14.2013

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How to Cite

Arturo Arias, B. L., García Restrepo, N., Uribe Echeverry, P. T., & Betancur Pérez, J. F. (2013). Colorectal cancer: clinical; molecular and genetics view. Archivos De Medicina , 13(2), 208-219. https://doi.org/10.30554/archmed.13.2.14.2013

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Brenda Lucia Arturo Arias

Docente investigador universidad de manizales

Natalia García Restrepo

Docente investigador universidad de manizales

Paula Tatiana Uribe Echeverry

Docente investigador universidad de manizales

Jhon Fredy Betancur Pérez

Docente investigador universidad de manizales

Show authors biography

Brenda Lucia Arturo Arias,

Médico cirujano, Especialista en gastroenterología.

Natalia García Restrepo,

Médico cirujano, Especialista en Genética Medica

Paula Tatiana Uribe Echeverry,

Los autores declaran no tener conflicto de intereses

Jhon Fredy Betancur Pérez,

Biólogo, Especialista en Biología Molecular y Biotecnología, Doctor en Ciencias

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Colorectal cancer

genetics

clinical diagnosis.

Colorectal cancer took the fourth leading cause of cancer death in the United States of America and the fifth leading cause of cancer death in Colombia and thus becomespublic health problem. 98% of colorectal cancers are adenocarcinomas and the
other 2% are lymphomas, carcinoids, and gastrointestinal stromal tumors, the clinical manifestations are related to the size and location of the lesion, 80% of reported cases of CRC not present a hereditary component making them sporadic CRC. The CRC is associated with the accumulation of mutations in tumor suppressor genes (p53, APC, SMAD, SCC, NM23), oncogenes (MYC and RAS) and DNA repair genes (MSH1, MSH6 and MLH2) these genetic alterations make this type of cancer a polygenic disorder, making it a classic model for studying the genetic basis of cancer.

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