Correlacion Entre El Indice Adipodectina/Resistina Y Albuminuria En Pacientes Diabeticos Tipo 2 Hipertensos

Alberto Francisco Rubio-Guerra; Hilda Vargas-Robles; Juan Antonio Suarez Cuenca; Saul Huerta Ramírez; Bruno Alfonso Escalante-Acosta

doi:10.30554/archmed.15.2.815.2015

Correlation between the adiponectin/resistin index and albuminuria in hypertensive type 2 diabetic patients

Correlacion Entre El Indice Adipodectina/Resistina Y Albuminuria En Pacientes Diabeticos Tipo 2 Hipertensos

Published 2015-12-27

https://doi.org/10.30554/archmed.15.2.815.2015

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Vol. 15 No. 2

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Artículos de Investigación

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Rubio-Guerra, A. F., Vargas-Robles, H., Suarez Cuenca, J. A., Huerta Ramírez, S., & Escalante-Acosta, B. A. (2015). Correlation between the adiponectin/resistin index and albuminuria in hypertensive type 2 diabetic patients. Archivos De Medicina , 15(2), 320-325. https://doi.org/10.30554/archmed.15.2.815.2015

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https://doi.org/10.30554/archmed.15.2.815.2015

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Rubio-Guerra, A. F., Vargas-Robles, H., Suarez Cuenca, J. A., Huerta Ramírez, S., & Escalante-Acosta, B. A. (2015). Correlation between the adiponectin/resistin index and albuminuria in hypertensive type 2 diabetic patients. Archivos De Medicina , 15(2), 320-325. https://doi.org/10.30554/archmed.15.2.815.2015

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Alberto Francisco Rubio-Guerra

Hospital General de Ticomán, SS DF. Universidad Nacional Autónoma de México

Hilda Vargas-Robles

CINVESTAV, México DF.

Juan Antonio Suarez Cuenca

Hospital 20 de noviembre del ISSSTE México DF

Saul Huerta Ramírez

Hospital General de Ticoman SS DF

Bruno Alfonso Escalante-Acosta

CINVESTAV Monterrey

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Alberto Francisco Rubio-Guerra,

Jefe de Enseñanza e Investigación. Hospital General de Ticomán.

Profesor adjunto al curso de especialización en Medicina Interna, Facultad de Medicina de la UNAM

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adiponectin

resistin

albuminuria

hypertension. type 2 diabetes.

Objective: to evaluate if the circulating levels of adiponectin an resistin, and the adiponectin/ resistin index, correlate with albuminuria in diabetic patients. Material and Methods: serum levels of adiponectin and resistin were measured by ELISA in 30
type-2 diabetic patients with never-treated hypertension. In all of them 24 hrs urinary albumin excretion, was measured. The adiponectin/resistin index was estimated using the following formula (1+log10 Resistin-log10 adiponectin). The relationship between adipocyokine levels and the adiponectin/resistin index with albuminuria was assessed by the Pearson correlation coefficient test. Results: a correlation between adiponectin
levels and albuminuria was not found (R= -0,09 p > 0,05), nor with resistin al urinary albumin excretion (R= 0,23 p>0,05), However, 24 hrs albuminuria correlated positively with the adiponectin/resistin index (R= 0,312, p<0,01). Conclusion: the results shown a correlation between the adiponectin/resistin index and renal damage in diabetic hypertensive patients. The adiponectin/resistin index may be a marker of diabetic nephropathy, and a therapeutic target.

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