Síndrome de Sjögren, más que un ojo seco

Andrés David Aránzazu Ceballos; Jerónimo Escobar Restrepo; Sergio Ramírez Pulgarín

doi:10.30554/archmed.15.2.788.2015

Sjögren syndrome, more than a dry eye

Síndrome de Sjögren, más que un ojo seco

Published 2015-12-31

https://doi.org/10.30554/archmed.15.2.788.2015

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Vol. 15 No. 2

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Aránzazu Ceballos, A. D., Escobar Restrepo, J., & Ramírez Pulgarín, S. (2015). Sjögren syndrome, more than a dry eye. Archivos De Medicina (Manizales), 15(2), 343-351. https://doi.org/10.30554/archmed.15.2.788.2015

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https://doi.org/10.30554/archmed.15.2.788.2015

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Aránzazu Ceballos, A. D., Escobar Restrepo, J., & Ramírez Pulgarín, S. (2015). Sjögren syndrome, more than a dry eye. Archivos De Medicina (Manizales), 15(2), 343-351. https://doi.org/10.30554/archmed.15.2.788.2015

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Andrés David Aránzazu Ceballos

Universidad Pontificia Bolivariana

Perfil Google Scholar

http://orcid.org/0000-0002-0867-4793

Jerónimo Escobar Restrepo

Universidad Pontificia Bolivariana

Sergio Ramírez Pulgarín

Universidad Pontificia Bolivariana

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Autoimmunity

xerophthalmia

rheumatology

Sjogren’s syndrome

genetics

environment.

Primary Sjögren’s syndrome (pSS) is a highly prevalent autoimmune exocrinopathy today, affecting 0.2 to 3% of the general population. SSP has been attributed a codependency
between genetic susceptibility of the individual, due to the presence of alleles of HLA DR and HLA DQ and environmental influences that lead to the development of the disease.
The SSP is characterized by loss of central tolerance, which causes a epithelitis linfomonocitarias by infiltrating cells, a process whose result acinar atrophy in exocrine glands. Clinical manifestations mainly fall into two groups: glandular manifestations such as xerostomia, xerophthalmia and parotid hypertrophy and extraglandular as arthralgia, neuropathy, fatigue, among others.The SSP is a challenge for clinicians because it requires a high index of suspicion,
due to the wide range of glandular and extraglandular demonstrations and a good implementation of specific tests and compliance with the classification criteria. Treatment of Sjögren’s syndrome depends on the symptoms and the glandular or extraglandular commitment. The management is based on the fulfillment of three pillars: general measures to prevent dryness, secretion stimulants and medication when there is systemic involvement. In recent years it has attracted interest in the use of monoclonal antibodies in the treatment of Sjögren’s syndrome, which have led to promising results as the use of
anti-CD20.

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