Immunolocalización de s100a4 y α-sma en tejidos gingivales de pacientes con hipertrofia gingival por tratamiento ortodóntico: estudio preliminar
Immunolocalización de s100a4 y α-sma en tejidos gingivales de pacientes con hipertrofia gingival por tratamiento ortodóntico: estudio preliminar Immunolocalization of s100a4 and α-sma in gingival tissues of patients with gingival hypertrophy due to orthodontic treatment: preliminary study
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Simanca Escorcia, V. ., Carmona Lorduy, M. ., & Díaz Caballero, A. . (2021). Immunolocalización de s100a4 y α-sma en tejidos gingivales de pacientes con hipertrofia gingival por tratamiento ortodóntico: estudio preliminar: Immunolocalization of s100a4 and α-sma in gingival tissues of patients with gingival hypertrophy due to orthodontic treatment: preliminary study. Archivos De Medicina , 21(1), 24-34. https://doi.org/10.30554/archmed.21.1.3693.2021
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Simanca Escorcia, V. ., Carmona Lorduy, M. ., & Díaz Caballero, A. . (2021). Immunolocalización de s100a4 y α-sma en tejidos gingivales de pacientes con hipertrofia gingival por tratamiento ortodóntico: estudio preliminar: Immunolocalization of s100a4 and α-sma in gingival tissues of patients with gingival hypertrophy due to orthodontic treatment: preliminary study. Archivos De Medicina , 21(1), 24-34. https://doi.org/10.30554/archmed.21.1.3693.2021
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- Jonathan Harris Ricardo, Leidy Álvarez Ricardo, Antonio Díaz Caballero, Diagnostic parameters of cleidocranial dysplasia: a low frequent disease , Archivos de Medicina : Vol. 17 No. 2
Objective: The present work seeks to determine the presence and distribution of markers of the epithelial-mesenchymal transition (EMT) (S-100A4 and alpha-smooth muscle actin-α-SMA) in gingival tissues of patients affected by Gingival overgrowth (GO) due to orthodontics. GO is an exaggerated increase in gingival tissue whose pathogenesis is unknown. However, it has been reported that the epithelial-mesenchymal transition as a process involved in other types of GO. Materials and methods: Descriptive study that included the analysis of gingival tissues of healthy individuals (n = 6) and patients with GO due to orthodontic treatment (n = 6). The identification and location of S-100A4 and α-SMA was performed by immunohistochemistry, determining the cell types involved in each expression. Results: In healthy individuals, a S100A4 label was observed in Langerhans cells and α-SMA, in the vascular endothelium of all samples analysed. However, in patients with GO due to orthodontics, intense staining of S100A4 was recorded in gingival fibroblasts, Langerhans cells, vascular endothelium, and areas adjacent to blood vessel rupture while α-SMA expression was present in the endothelium vascular and gingival fibroblasts. Conclusion: Differential immunomarking of EMT markers in gingival tissues of patients with gingival overgrowth due to orthodontics suggests the role of EMT in the pathogenesis of this pathology
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