Efecto de atorvastatina sobre los niveles de biopterinas y la relación bh4/bh2 en pacientes diabéticos:

Alberto Francisco Rubio-Guerra; Leonardo Del-Valle Mondragon

doi:10.30554/archmed.14.2.303.2014

Evaluate the effect of atorvastatin on biopterin levels and the BH4/BH2 ratio in hypertensive type-2 diabetic patients

Efecto de atorvastatina sobre los niveles de biopterinas y la relación bh4/bh2 en pacientes diabéticos:

Published 2014-12-31

https://doi.org/10.30554/archmed.14.2.303.2014

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Vol. 14 No. 2

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Artículos de Investigación

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Rubio-Guerra, A. F., & Del-Valle Mondragon, L. (2014). Evaluate the effect of atorvastatin on biopterin levels and the BH4/BH2 ratio in hypertensive type-2 diabetic patients. Archivos De Medicina , 14(2), 231-325. https://doi.org/10.30554/archmed.14.2.303.2014

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https://doi.org/10.30554/archmed.14.2.303.2014

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Rubio-Guerra, A. F., & Del-Valle Mondragon, L. (2014). Evaluate the effect of atorvastatin on biopterin levels and the BH4/BH2 ratio in hypertensive type-2 diabetic patients. Archivos De Medicina , 14(2), 231-325. https://doi.org/10.30554/archmed.14.2.303.2014

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Alberto Francisco Rubio-Guerra

Hospital general de ticomán, ss df. Universidad nacional autónoma de méxico

Leonardo Del-Valle Mondragon

Instituto nacional de cardiología

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Alberto Francisco Rubio-Guerra,

Jefe de enseñanza e investigación. Hospital general de ticomán.

Profesor adjunto al curso de especialización en medicina interna, facultad de medicina de la unam

Leonardo Del-Valle Mondragon,

Servicio de farmacología, instituto nacional de cardiología

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Tetrahydrobiopterin

dihydrobiopterin

dtorvastatin

diabetic patients.

To evaluate the effect of atorvastatin on biopterin levels and the BH4/BH2 ratio in hypertensive type-2 diabetic patients. Material and Methods: 20 type-2 diabetic patients’ naives to statins and inhibitors of the renin angiotensin systems received atorvastatin 10 mg once a day during 3 months. BH4 and BH2 were measured by reverse phase high performance liquid chromatography with fluorescence detection at the beginning and end of the study. Patients were evaluated monthly for blood pressure, fasting serum glucose, lipid profile and adverse events. Statistical analysis was performed with the Shapiro-Wilk and Wilcoxon test. Results: All patients experienced a significant reduction of lipid values. Atorvastatin increased the levels of BH4 (5.4 to 9.1, p=0.047), decreased the levels of BH2 (7.4 to 6.99, p= 0.60), and improved the BH4/ BH2 ratio (0.83 to 1.85 p= 0.016) No patient suffered adverse events. Conclusion: Our
results shown that atorvastatin has beneficial effects on biopterin parameters. This may explain, at least in part, the cardiovascular effects seen with statins in diabetic patients.

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