Sickle Cell Disease: Clinical-Pathological Correlation

Anemia de Células Falciformes: Correlación Clínico-Patológica

Sickle cell disease is the most common inherited hematologic disorder worldwide. It is due to the presence of abnormal hemoglobins (HbS and its different genotypes) as a result of a mutation in the globin chains. The main clinical triad of the disease consists of vaso-occlusive events, chronic hemolytic anemia and functional asplenia. Today, all kinds of complications associated with the disease have been documented, among which are: stroke, acute myocardial infarction, pulmonary hypertension, venous thromboembolism, infections, necrosis of the renal papilla, chronic kidney disease, ulceration, diseases of the hepatobiliary apparatus and avascular necrosis. In conclusion, it is of vital importance to carry out a correct clinical and therapeutic approach of patients with sickle cell disease in order to prevent and treat the complications associated with this condition.