“All-or-nothing” principle: ¿misinterpreted concept or wrong dogma?
Principio del todo o nada ¿un concepto mal interpretado o un dogma equivocado?. / “all-or-nothing” principle: ¿misinterpreted concept or wrong dogma?
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barco ríos, J., duque parra, J. eduardo, & barco cano, J. alexandra. (2014). “All-or-nothing” principle: ¿misinterpreted concept or wrong dogma?. Archivos De Medicina , 14(1), 144-149. https://doi.org/10.30554/archmed.14.1.165.2014
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barco ríos, J., duque parra, J. eduardo, & barco cano, J. alexandra. (2014). “All-or-nothing” principle: ¿misinterpreted concept or wrong dogma?. Archivos De Medicina , 14(1), 144-149. https://doi.org/10.30554/archmed.14.1.165.2014
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principle “all or none” that applies to excitable cells, is inadequate and contradictory
phrase, because it lends itself to misinterpretation and electrostatic phenomenon
blurs the channels underlying of voltage-gated Na+ (Nav). Discussion: The segments
voltage sensors S4 of Na+ channels present arginine residues with positive charge,
which interact with the internal environment and generate electric repulsion caused by
the pore opening of the channel through which enters the sodium ions and depolarize
membrane. As above occurs only when the membrane reaches a threshold level, then,
the phrase “all or nothing” principle, in physiology classic texts and indexed journals is
contradictory and meaningless. Conclusion: Since it is a purely electrical phenomenon
which is triggered when the excitable cell membrane reaches a fair variation of voltage
(threshold level), we propose that rather than continue to use the traditional phrase “all
or nothing” principle, is used the phrase “electrostatic effect”, to be more consistent
with the molecular and electrical events that actually occur in the excitable membrane.
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