Risk factors for non-alcoholic fatty liver disease in symptomatic gallbladder disease patients.

Factores de riesgo para hígado graso no-alcohólico en pacientes con colelitiasis sintomática.

Objective: identify the prevalence and risk factors associated to non-alcoholic fatty liver disease in patients with symptomatic cholelithiasis. Material and methods: Patients
with symptomatic cholelithiasis with surgical treatment (laparoscopic cholecystectomy) and hepatic biopsy. Inclusion criteria were: diagnosis of symptomatic cholelithiasis,
age from 18 to 65 years old, diagnostic hepatic biopsy, and informed consent signed. Variables were: age, sex, weight, height, body mass index, waist circumference, hip circumference, waist-hip index, blood pressure, fasting glucose, lipid panel and metabolic syndrome. Patients were divided into two groups: group I with non-alcoholic fatty liver disease and group II with normal liver. Results: 248 patients were included, 85,5%
were females and 14,5% were males. The prevalence of non-alcoholic fatty liver disease was 77,5%. There were statistical differences between groups in variables: weight (p=<0,0001), waist circumference (p=<0,0001), hip circumference (p=<0,0001), blood pressure (p=<0,0001), HDL levels (p=<0,0001), and presence of metabolic syndrome
(p=<0,0001). Conclusion: overweight and obesity determined by body mass index, HDL levels, and metabolic syndrome are independent risk factors that increase the
prevalence of non-alcoholic fatty liver disease in patients with symptomatic cholelithiasis.