Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical
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Objective: to determine the relationship and association of early sepsis with interleukin-
6 measured in umbilical blood, as well as gestational age and birth weight, prenatal
history of the mother pathologies during pregnancy, in newborns at the Neonatology
Service of Carlos Andrade Marín Hospital (Quito). Material and methods: epidemiological,
observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams, cutoff point interleukin 6 ≤14pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, infection of the urinary tract
during pregnancy 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of
patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship
of prenatal pre-maternity of the mother and neonatal sepsis, p<0.05; relationship
between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia and urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: it is concluded that there is a correlation of risk factors, such as gestational age in weeks, weight, prenatal preeclampsia, UTI prior to birth, vaginitis/vaginosis, and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age
was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.
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Referencias
Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK
Jr, Smith PB, et al. Early and late onset sepsis in
very-low-birth-weight infants from a large group
of neonatal intensive care units. Early Hum Dev
; 88(Suppl 2):S69-74. DOI: 10.1016/S0378-
(12)70019-1
Simonsen KA, Anderson-Berry AL, Delair SF,
Davies HD. Early-onset neonatal sepsis. Clin
Microbiol Rev 2014; 27(1):21-47. DOI: 10.1128/
CMR.00031-13
Bedford Russell AR, Kumar R. Early onset neonatal
sepsis: diagnostic dilemmas and practical
management. Arch Dis Child Fetal Neonatal
Ed. 2015; 100(4): F350-4. DOI: 10.1136/archdischild-
-306193
Fan Y, Yu JL. Umbilical blood biomarkers for
predicting early-onset neonatal sepsis. World J
Pediatr. 2012; 8(2):101-8. DOI: 10.1007/s12519-
-0347-3
Chiesa C, Pacifico L, Natale F, Hofer N, Osborn
JF, Resch B. Fetal and early neonatal interleukin-
response. Cytokine 2015; 76(1): 1-12. DOI:
1016/j.cyto.2015.03.015
Su H, Chang SS, Han CM, Wu KY, Li MC, Huang
CY, et al. Inflammatory markers in cord blood or
maternal serum for early detection of neonatal
sepsis-a systemic review and meta-analysis.
J Perinatol 2014; 34(4):268-74. DOI: 10.1038/
jp.2013.186
Sugitharini V, Prema A, Berla Thangam E. Inflammatory
mediators of systemic inflammation in
neonatal sepsis. Inflamm Res 2013; 62(12):1025-
DOI: 10.1007/s00011-013-0661-9
Celik IH, Demirel G, Uras N, Oguz ES, Erdeve O,
Dilmen U. [The role of serum interleukin-6 and
C-reactive protein levels for differentiating aetiology
of neonatal sepsis]. Arch Argent Pediatr 2015;
(6):534-7. DOI: 10.5546/aap.2015.534
Khaertynov KS, Boichuk SV, Khaiboullina SF,
Anokhin VA, Andreeva AA, Lombardi VC, et al.
Comparative Assessment of Cytokine Pattern
in Early and Late Onset of Neonatal Sepsis.
J Immunol Res 2017; 2017:8601063. DOI:
1155/2017/8601063
Steinberger E, Hofer N, Resch B. Cord blood
procalcitonin and Interleukin-6 are highly
sensitive and specific in the prediction
of early-onset sepsis in preterm infants.
Scand J Clin Lab Invest 2014; 74(5):432-6. DOI:
3109/00365513.2014.900696
Celik IH, Demirel FG, Uras N, Oguz SS, Erdeve
O, Biyikli Z, Dilmen U. What are the cut-off levels
for IL-6 and CRP in neonatal sepsis?. J Clin Lab
Anal 2010; 24(6):407-12. DOI: 10.1002/jcla.20420
Boskabadi H, Zakerihamidi M. Evaluate the diagnosis
of neonatal sepsis by measuring interleukins:
A systematic review. Pediatr Neonatol 2018; 59(4):
-338. DOI: 10.1016/j.pedneo.2017.10.004
Machado JR, Soave DF, da Silva MV, de Menezes
LB, Etchebehere RM, Monteiro ML, et al.
Neonatal sepsis and inflammatory mediators.
Mediators Inflamm 2014; 2014:269681. DOI:
1155/2014/269681
Mirzarahimi M, Barak M, Eslami A, Enteshari-Moghaddam
A. The role of interleukin-6 in the early
diagnosis of sepsis in premature infants. Pediatr
Rep 2017; 9(3):7305. DOI: 10.4081/pr.2017.7305
Barug D, Goorden S, Herruer M, Müller M, Brohet
R, de Winter P. Reference values for interleukin-6
and interleukin-8 in cord blood of healthy term
neonates and their association with stress-related
perinatal factors. PLoS One 2014; 9(12):
e114109. DOI: 10.1371/journal.pone.0114109
Ye Q, Du LZ, Shao WX, Shang SQ. Utility of cytokines
to predict neonatal sepsis. Pediatr Res
; 81(4):616-621. DOI: 10.1038/pr.2016.267.E
Chauhan N, Tiwari S, Jain U. Potential biomarkers
for effective screening of neonatal sepsis
infections: An overview. Microb Pathog 2017;
:234-242. DOI: 10.1016/j.micpath.2017.03.042
Mirzarahimi M, Barak M, Eslami A, Enteshari-Moghaddam
A. The role of interleukin-6 in the early
diagnosis of sepsis in premature infants. Pediatr
Rep 2017; 9(3): 7305. DOI: 10.4081/pr.2017.7305
Chiesa C, Pacifico L, Natale F, Hofer N, Osborn
JF, Resch B. Fetal and early neonatal interleukin-
response. Cytokine. 2015; 76(1):1-12. DOI:
1016/j.cyto.2015.03.015
Boskabadi H, Zakerihamidi M. Evaluate the diagnosis
of neonatal sepsis by measuring interleukins:
A systematic review. Pediatr Neonatol 2018; 59(4):
-338. DOI: 10.1016/j.pedneo.2017.10.004
Sorokin Y, Romero R, Mele L, Iams JD, Peaceman
AM, Leveno KJ, et al. Umbilical cord serum
interleukin-6, C-reactive protein, and myeloperoxidase
concentrations at birth and association
with neonatal morbidities and long-term neurodevelopmental
outcomes. Am J Perinatol 2014;
(8):717-26. DOI: 10.1055/s-0033-1359723
Alves JB, Gabani FL, Ferrari RAP, Tacla MTGM,
Linck Júnior A. Neonatal sepsis: mortality in a
municipality in southern Brazil, 2000 to 2013.
Rev Paul Pediatr 2018; 36(2): 132-140. DOI:
1590/1984-0462/;2018;36;2;00001
Molloy EJ, O’Neill SM. Neonatal Escherichia
coli sepsis: possible effects of gender, type of
surfactant, or time to initiation of antibiotics?.
Am J Obstet Gynecol 2006; 194(4):1201-2. DOI:
1016/j.ajog.2005.07.088
Kurt AN, Aygun AD, Godekmerdan A, Kurt A, Dogan
Y, Yilmaz E. Serum IL-1beta,IL-6, IL-8, and TNF-alpha
levels in early diagnosis and management
of neonatal sepsis. Mediators Inflamm 2007; 2007:
DOI: 10.1155/2007/31397
Bhandari V. Effective Biomarkers for Diagnosis of
Neonatal Sepsis. J Pediatric Infect Dis Soc 2014;
(3):234-45. DOI: 10.1093/jpids/piu063
Sugitharini V, Prema A, Berla Thangam E. Inflammatory
mediators of systemic inflammation in
neonatal sepsis. Inflamm Res 2013; 62(12):1025-
DOI: 10.1007/s00011-013-0661-9
Krauss-Silva L, Moreira ME, Alves MB, Rezende
MR, Braga A, Camacho KG, et al. Randomized
controlled trial of probiotics for the prevention
of spontaneous preterm delivery associated with
intrauterine infection: study protocol. Reprod
Health 2010; 7:14. DOI: 10.1186/1742-4755-7-14
Pavare J, Grope I, Kalnins I, Gardovska D. Highmobility
group box-1 protein, lipopolysaccharide-
binding protein, interleukin-6 and C-reactive
protein in children with community acquired
infections and bacteraemia: a prospective study.
BMC Infect Dis 2010; 10:28. DOI: 10.1186/1471-
-10-28