Glucosa 6 fosfato deshidrogenasa: características bioquímicas y moleculares. Prevalencia de la deficiencia

Gilberto Antonio Bastidas Pacheco; Hilda Pérez; Esmeralda Vizzi

doi:10.30554/archmed.15.1.667.2015

Glucose-6-phosphate dehydrogenase: biochemical and molecular characteristics. Prevalence of deficiency

Glucosa 6 fosfato deshidrogenasa: características bioquímicas y moleculares. Prevalencia de la deficiencia

Published 2015-06-30

https://doi.org/10.30554/archmed.15.1.667.2015

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Vol. 15 No. 1

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Bastidas Pacheco, G. A., Pérez, H., & Vizzi, E. (2015). Glucose-6-phosphate dehydrogenase: biochemical and molecular characteristics. Prevalence of deficiency. Archivos De Medicina , 15(1), 138-150. https://doi.org/10.30554/archmed.15.1.667.2015

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https://doi.org/10.30554/archmed.15.1.667.2015

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How to Cite

Bastidas Pacheco, G. A., Pérez, H., & Vizzi, E. (2015). Glucose-6-phosphate dehydrogenase: biochemical and molecular characteristics. Prevalence of deficiency. Archivos De Medicina , 15(1), 138-150. https://doi.org/10.30554/archmed.15.1.667.2015

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Gilberto Antonio Bastidas Pacheco

Universidad de carabobo

Hilda Pérez

Instituto venezolano de investigaciones científicas (ivic).

Esmeralda Vizzi

Instituto venezolano de investigaciones científicas (ivic).

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Gilberto Antonio Bastidas Pacheco,

Médico, master en gerencia de la educación, master en protozoologia, doctor en parasitologia. con diplomados en alta gerencia y salud laboral. Profesor asociado departamento de salud publica, escuela de medicina, facultad de ciencias de la salud.

Hilda Pérez,

Biologa con doctorado en inmunologia.

Esmeralda Vizzi,

Biologa con doctorado en biologia molecular.

glucose-6-phosphate dehydrogenase

erythrocytes

hemolytic anemia

malaria

oxidative stress.

Glucose-6-phosphate dehydrogenase (G6PD) is a cytoplasmic enzyme that is distributed in all cells of the organism and that catalyzes the first step in the pentose pathway in which glucose-6-phosphate (G6P) is converted to 6-fosfogluconato (6FG)
and reduced NADP to NADPH, which is essential to protect erythrocytes from oxidative damage process. The G6PD deficiency is the most common erythroenzymopathy, is
recessive and X-linked, with worldwide distribution and high genetic and biochemical heterogeneity. A review of biochemical aspects, structure, genetics, molecular, enzymatic
defect, prevalence of disability in the world and in Venezuela, and the role of G6PD deficiency in the treatment of malaria was conducted by the increased risk of hemolysis involves the tendency to increase the total dose of primaquine in subjects
malaria, particularly in regions where infection by Plasmodium vivax predominates.

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