Temporal prediction of the behavior between the number of leukocytes and CD4 + T lymphocytes in HIV positive patients with antiretroviral therapy

Temporal prediction of the behavior between the number of leukocytes and CD4 + T lymphocytes in HIV positive patients with antiretroviral therapy

Published 2023-09-04


https://doi.org/10.30554/archmed.23.1.4157.2023
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Vol. 23 No. 1 (2023): .
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Artículos de Investigación
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Rodriguez, J., Pérez, C. ., Pardo, J. ., Barrios, F. ., & González, M. A. . (2023). Temporal prediction of the behavior between the number of leukocytes and CD4 + T lymphocytes in HIV positive patients with antiretroviral therapy. Archivos De Medicina (Manizales), 23(1). https://doi.org/10.30554/archmed.23.1.4157.2023
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Rodriguez, J., Pérez, C. ., Pardo, J. ., Barrios, F. ., & González, M. A. . (2023). Temporal prediction of the behavior between the number of leukocytes and CD4 + T lymphocytes in HIV positive patients with antiretroviral therapy. Archivos De Medicina (Manizales), 23(1). https://doi.org/10.30554/archmed.23.1.4157.2023

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Javier Rodriguez
Director of the Insight Group
https://orcid.org/0000-0002-4585-3010 ORCID
Calos Pérez
Services and advice in Infectology
https://orcid.org/0000-0002-5103-5938 ORCID
Juan Pardo
Scientific Director. Mederi University Hospital.
https://orcid.org/0000-0003-0084-3449 ORCID
Freddy Barrios
Research group in Epidemiology and Biostatistics. CES University
https://orcid.org/0000-0002-0990-1679 ORCID
María Alejandra González
Odontoposgrados Group. Faculty of Dentistry. Cooperative University of Colombia
https://orcid.org/0000-0002-6299-2135 ORCID
Show authors biography

Javier Rodriguez,

MD, Director of the Insight Group. Colombian Neurosurgery Association. Mederi University Hospital. Bogotá Colombia.";}

Calos Pérez,

Spec. in Infectious disease. Services and advice in Infectology. Marly's Clinic. Bogotá Colombia.

Juan Pardo,

Scientific Director. Mederi University Hospital. Bogotá Colombia.

Freddy Barrios,

MD. Research group in Epidemiology and Biostatistics. CES University. Medellin Colombia.

María Alejandra González,

Researcher Odontoposgrados Group. Faculty of Dentistry. Cooperative University of Colombia. Headquarters Bogotá

Introduction: The elevated cost of flow cytometry for the following up of CD+ T lymphocyte counts has justified the search for predictive methodologies of this values that contribute to simplify and reduce costs of the therapeutic management of patients with HIV/AIDS. Objective: to establish the possible predictive mathematical correspondences between the CD4 + count> 500 cells/μL3 from the amount of leukocytes/μL3. Methodology: A mathematical induction was carried out with eight samples in time to establish a predictive pattern between the leukocyte count in a count of CD4+ > 500 cells/μL3. The validation of the predictive pattern was confirmed in 62 samples that had CD4+ counts previously masked. Then, the probability of success of the pattern was established as well as sensitivity and specificity. Results: the mathematical pattern of the eight samples revealed that, for a CD4 + count> 500 cells/μL3, a value greater than 3.7 leukocytes/μL3 is presented, with a value of one when calculating the probability and, of 100% when calculating the sensitivity and specificity. Conclusions: the present study revealed a deterministic mathematical order from which it is possible to establish direct correspondences between leukocyte count leukocytes/μL3 greater than 3.7 and CD4 + greater than 500 cells/μL3 in the context of probability theory.

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