Non-hormonal treatment of genitourinary syndrome of menopause
Tratamiento no hormonal del síndrome genitourinario de la menopausia Non-hormonal treatment of genitourinary syndrome of menopause
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The genitourinary syndrome of menopause (SGUM) describes the symptoms and signs of the vulvo-vaginal and lower urinary tract, of a chronic and progressive nature, secondary to a clinical state of hypoestrogenism that characterizes postmenopause. The present review aims to describe and analyze the different non-hormone therapeutic alternatives, with their advantages and disadvantages, in order to offer readers a full range of options when establishing treatment in a woman with SGUM. A database search, including original research, expert consensus, systematic reviews, meta-analysis, in Spanish and English, has been conducted since 1990. We reviewed the current evidence for various non-hormonal pharmacological and non-pharmacological therapeutic modalities, finding that moisturizers and lubricants are the first line of therapy to provide short-term relief from vaginal dryness (mild to moderate) and dyspareunia; however, treatment must be individualized. It is concluded that there are numerous treatments available, each with benefits and limitations. We highlight the substantial gaps, in the scientific evidence, of safe and effective therapies, as well as the need for future research.
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