Immunometabolic response in older adults with urinary tract infection and phylogenetic classification of Escherichia coli in elderly homes

Clasificación filogenética de Escherichia coli uropatógena y respuesta inmunometabólica en adultos mayores con infección urinaria en casas de reposo

Objectives: To characterize the immunometabolic response in the urine of elderly patients infected with uropathogenic Escherichia coli resident in elderly homes and determine its phylogenetic frequency. Materials and methods: Descriptive and observational study in which 24 patients with urinary tract infection and 17 patients without urinary tract infection were enrolled. Were quantified Iron and TNF – α in urine by spectrophotometric methods, the antioxidant capacity by ABTS + * assay and the phylogenetic determination of E. coli by the Clermont method. Results: The concentration of iron, TNF - α and the antioxidant capacity in urine in patients with urinary tract infection were 175.40 mg / L, 70.11 pg / mL and 1229.75 mg / mL eq-VitC, while in patients without infection the values were of 67.4 mg / L (p = 0.001), 87.16 pg / mL (p = 0.08) and 1069.14 mg / mL eq-VitC (p = 0.61) respectively. In addition, 11 E. coli belonging to group B2 and 13 grouped in non - B2 (A, B1, D and E) were found. Conclusions: High availability of iron in the urine of elderly patients with urinary tract infection is evidenced, which stimulates bacterial proliferation. There is a high antioxidant capacity in the urine of patients with urinary tract infection and a greater clonal presence of non-B2 type E.coli in the urine of patients residing in elderly homes.