Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical

Publicado 2019-07-24


https://doi.org/10.30554/archmed.19.2.3298.2019
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Vol. 19 Núm. 2 (2019)
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Artículos de Investigación
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González Andrade, F., Castillo Rojas, A. ., & Aguinaga Romero, G. (2019). Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood: Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical. Archivos De Medicina, 19(2). https://doi.org/10.30554/archmed.19.2.3298.2019
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https://doi.org/10.30554/archmed.19.2.3298.2019
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González Andrade, F., Castillo Rojas, A. ., & Aguinaga Romero, G. (2019). Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood: Factores de riesgo maternos en recién nacidos a término con sepsis de aparición temprana relacionada con interleucina-6 en sangre umbilical. Archivos De Medicina, 19(2). https://doi.org/10.30554/archmed.19.2.3298.2019

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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

Fabricio González Andrade
Central University of Ecuador, Faculty of Medical Sciences, Traslational Medicine Unit. Address: Iquique N14-121 and Sodiro-Itchimbía, Sector El Dorado, 170403, Quito, Ecuador. Phone: +593 9984536414
Andrea Castillo Rojas
Central University of Ecuador
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https://orcid.org/0000-0002-4878-4700 ORCID
Gabriela Aguinaga Romero
Central University of Ecuador
https://orcid.org/0000-0002-6274-2195 ORCID
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Andrea Castillo Rojas,

Translational Medicine Unit, Faculty of Medical Sciences at Central University of
Ecuador. Quito, Ecuador

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Objective: to determine the relationship and association of early sepsis with interleukin-
6 measured in umbilical blood, as well as gestational age and birth weight, prenatal
history of the mother pathologies during pregnancy, in newborns at the Neonatology
Service of Carlos Andrade Marín Hospital (Quito). Material and methods: epidemiological,
observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams, cutoff point interleukin 6 ≤14pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, infection of the urinary tract
during pregnancy 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of
patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship
of prenatal pre-maternity of the mother and neonatal sepsis, p<0.05; relationship
between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia and urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: it is concluded that there is a correlation of risk factors, such as gestational age in weeks, weight, prenatal preeclampsia, UTI prior to birth, vaginitis/vaginosis, and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age
was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.

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