Mitochondria: from the cell to the clinic; case of sepsis

Mitocodria: de la célula al clínica, caso de la sepsis

Published 2014-12-16


https://doi.org/10.30554/archmed.14.2.268.2014
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Sánchez Díaz, E., Gallego González, D., Marín Cárdenas, J. S., & Agudelo Vélez, C. A. (2014). Mitochondria: from the cell to the clinic; case of sepsis. Archivos De Medicina (Manizales), 14(2), 285-296. https://doi.org/10.30554/archmed.14.2.268.2014
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Sánchez Díaz, E., Gallego González, D., Marín Cárdenas, J. S., & Agudelo Vélez, C. A. (2014). Mitochondria: from the cell to the clinic; case of sepsis. Archivos De Medicina (Manizales), 14(2), 285-296. https://doi.org/10.30554/archmed.14.2.268.2014

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Emmanuel Sánchez Díaz
Daniel Gallego González
Juan Sebastián Marín Cárdenas
Camilo Andrés Agudelo Vélez
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Emmanuel Sánchez Díaz,

Estudiante de medicina. Grupo de Investigación de Biología de Sistemas, Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana. Medellín, Colombia.

Daniel Gallego González,

Estudiante de medicina. Grupo de Investigación de Biología de Sistemas, Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana. Medellín, Colombia.

Juan Sebastián Marín Cárdenas,

Estudiante de medicina. Grupo de Investigación de Biología de Sistemas, Escuela de Ciencias de la Salud, Universidad Pontificia Bolivariana. Medellín, Colombia.

Camilo Andrés Agudelo Vélez,

Médico, MSc en Administración en Servicios de Salud. Coordinador de Gestión Clínica, Clínica Universitaria Bolivariana, Universidad Pontificia Bolivariana. Medellín, Colombia.

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Mitochondria has been identified as a key organelle in the pathophysiological process of several clinical disorders, especially those ones that involves metabolic processes.Multiple mechanisms, such as metabolic pathways of biological interactions, havebeen described in severe systemic inflammatory disorders such as sepsis. Particularly, the mean role of the oxidative stress as a marker of mitochondrial dysfunction has elucidated molecular target of clinical interest. From these considerations, it has been possible to synthesize molecules with selective therapeutic activity to counteract the mitochondrial alterations and thereby improve the prognosis and survival of patients suffering from high morbidity and mortality diseases, providing a sample scenario of the knowledge evolution from the cell to the clinical situation in a septic patient.

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