Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

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Fabricio González Andrade


Background: to determine the relationship and association of early sepsis with interleukin-6 measured in umbilical blood, as well as gestational age and birth weight, prenatal history of the mother pathologies during pregnancy, in full-term newborns at the Neonatology Service of Carlos Andrade Marín Hospital (Quito). Subjects and methods: epidemiological, observational, analytical, cross-sectional. 200 newborns were analyzed. IL-6 was determined by Elisa. Results: newborn mean gestational age 38.4±2 weeks, mean weight 2871±532.4 grams,  cutoff point interleukin 6 ≤14pg/uL; mean of IL6. 58±99,1 pg/uL; male sex was 43.9%, female sex 56.1%; preeclampsia of the mother 22.4%, prenatal infection of the urinary tract 20.4%; vaginitis/vaginosis 19.4%; IL6 values ≤ 14 pg/uL in 63.3% of patients; IL6 values of >14 pg/uL 36.7%; relationship with sepsis in all, p<0.05; relationship of prenatal pre-maternity of the mother and neonatal sepsis. p<0.05; relationship between vaginitis/vaginosis of the mother with neonatal sepsis; p<0.05; OR: 38.88 IC95% (4.912-307.728); association between sepsis and risk factors, IL6, gestational age in weeks, weight, prenatal preeclampsia, prenatal urinary tract infection, vaginitis/vaginosis, p<0.05. Conclusion: It is concluded that there is a relationship of risk factors, such as, gestational age in weeks, weight, prenatal preeclampsia, prenatal UTI, vaginitis/vaginosis and values of interleukin 6 ≤ 14 pg/uL. The mean gestational age was 38.4 weeks, and average weight 2871 grams in the newborns analyzed.


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1. Hornik CP, Fort P, Clark RH, se incluyen hasta 6 autores et al. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Título de la referencia en negrita Early Hum Dev abrerviatura de la revista en itálica y sin puntuación 2012; 88:S69-S74. DOI: incluir el DOI cuando la referencia lo tenga
2. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev sin punto final y en itálica 2014 Jan no se incluye ni día ni mes de publicación ; un espacio después de ; 27(1):21-47. DOI: 10.1128/CMR.00031-13
3. Bedford-Russell AR, Kumar R. Early onset neonatal sepsis: diagnostic dilemmas and practical management. Arch Dis Child Fetal Neonatal Ed 2015l; 100(4):F350-4. DOi:
4. Schuchat A. Neonatal group B streptococcal disease-screening and prevention. N Engl J Med 2000; 343:209–210. DOI:
5. Fan Y, Yu JL. Umbilical blood biomarkers for predicting early-onset neonatal sepsis. World J Pediatr 2012; 8(2):101-8. DOI:
6. Chiesa C, Pacifico L, Natale F, Hofer N, Osborn JF, Resch B. Fetal and early neonatal interleukin-6 response. Cytokine 2015; 76(1):1-12. DOI:
7. Su H, Chang SS, Han CM, Wu KY, Li MC, Huang CY, Lee CL, Wu JY, Lee CC. Inflammatory markers in cord blood or maternal serum for early detection of neonatal sepsis-a systemic review and meta-analysis. J Perinatol 2014; 34(4):268-74. DOI:
8. Sugitharini V, Prema A, Berla Thangam E. Inflammatory mediators of systemic inflammation in neonatal sepsis. Inflamm Res 2013; 62(12):1025-34. DOI:
9. Celik IH, Demirel G, Uras N, Oguz ES, Erdeve O, Dilmen U. [The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis]. Arch Argent Pediatr 2015; 113(6):534-7. DOI:
10. Khaertynov KS, Boichuk SV, Khaiboullina SF, et al. Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis. J Immunol Res 2017; 2017:8601063. DOI:

Favor corregir el resto de referencias según el modelo de las 10 primeras

11. Steinberger E, Hofer N, Resch B. Cord blood procalcitonin and Interleukin-6 are highly sensitive and specific in the prediction of early-onset sepsis in preterm infants. Scand J Clin Lab Invest. 2014 Aug; 74(5):432-6.
12. Celik IH, Demirel FG, Uras N, et al. What are the cut-off levels for IL-6 and CRP in neonatal sepsis? J Clin Lab Anal. 2010; 24(6):407-12.
13. Boskabadi H, Zakerihamidi M. Evaluate the diagnosis of neonatal sepsis by measuring ILs: A systematic review. Pediatr Neonatol. 2017 Oct 20. pii: S1875-9572(16)30307-2.
14. Chauhan N, Tiwari S, Jain U. Potential biomarkers for effective screening of neonatal sepsis infections: An overview. Microb Pathog. 2017 Jun; 107: 234-242.
15. Machado JR, Soave DF, da Silva MV, et al. Neonatal sepsis and inflammatory mediators. Mediators Inflamm. 2014; 2014: 269681.
16. Mirzarahimi M, Barak M, Eslami A, Enteshari-Moghaddam A. The role of interleukin-6 in the early diagnosis of sepsis in premature infants. Pediatr Rep. 2017 Oct 6; (3):7305.
17. Barug D, Goorden S, Herruer M, et al. Reference values for interleukin-6 and interleukin-8 in cord blood of healthy term neonates and their association with stress-related perinatal factors. PLoS One. 2014 Dec 8; 9(12):e114109.
18. Miklaszewska M, Korohodai P, Kwinta P, et al. Clinical validity of urinary interleukin 18 and interleukin 6 determinations in preterm newborns. Przegl Lek. 2015; 72 (11): 589-96.
19. Tskimanauri N. Epidemiological features of the perinatal risk factors and neonatal outcomes in Georgia-pilot study. Georgian Med News. 2017 Oct; (271): 38-44.
20. Celik IH, Demirel G, Uras N, et al. The role of serum interleukin-6 and C-reactive protein levels for differentiating aetiology of neonatal sepsis. Arch Argent Pediatr. 2015 Dec 1; 113(6):534-7.
21. Boskabadi H, Maamouri G, Tavakol-Afshari J, et al. Evaluation of serum interleukins-6. 8 and 10 levels as diagnostic markers of neonatal infection and possibility of mortality. Iran J Basic Med Sci. 2013 Dec; 16(12): 1232-7.
22. Boskabadi H, Zakerihamidi M. Evaluate the diagnosis of neonatal sepsis by measuring interleukins: A systematic review. Pediatr Neonatol. 2018 Aug; 59(4):329-338.
23. Sorokin Y, Romero R, Mele L, et al. Umbilical cord serum interleukin-6. C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes. Am J Perinatol. 2014 Sep; 31(8):717-26.
24. Alves JB, Gabani FL, Ferrari RAP, et al. Neonatal sepsis: mortality in a Municipality in southern Brazil. 2000 to 2013. Rev Paul Pediatr. 2018 Jan 15.
25. Molloy EJ, O'Neill SM. Neonatal Escherichia coli sepsis: possible effects of gender, type of surfactante, or time to initiation of antibiotics? Am J Obstet Gynecol. 2006 Apr; 194(4):1201-2.
26. Chaudhry BY, Akhtar N, Balouch AH. Vaginal carriage rate of group B Streptococcus in pregnant women and its transmission to neonates. J Ayub Med Coll Abbottabad. 2010 Oct-Dec; 22(4):167-70.
27. Herz K, Wohlmuth P, Liedtke B, et al. Late preterms: the influence of foetal gender on neonatal outcome. Z Geburtshilfe Neonatol. 2012 Jun; 216(3):141-6.
28. Rao YB, Yang J, Cao B, et al. Predictive effect of neonatal morbidities on the poor outcomes at 12 months corrected age in very low birth weight premature infants. Zhonghua Er Ke Za Zhi. 2017 Aug 2; 55(8):608-612.
29. Krauss-Silva L, Moreira ME, Alves MB, et al. Randomized controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with intrauterine infection: study protocol. Reprod Health. 2010 Jun 30; 7:14.
30. Pavare J, Tanteo, Kalnins I, Gardovska D. High-mobility group box-1 protein, lipopolysaccharide-binding protein, interleukin-6 and C-reactive protein in children with community acquired infections and bacteraemia: a prospective study. BMC Infect Dis. 2010 Feb 16; 10: 28.

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